http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7884121-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a23032a0d3404f90cbe4ca57c9ea8d6f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-54 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4172 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-64 |
| filingDate | 2007-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afb6810120c045e3df0eda416fdede7a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53afcbbb526b8cda873ea3845b2153db http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_11dc25f28b8a751a2dc4397dd2c74cd2 |
| publicationDate | 2011-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-7884121-B2 |
| titleOfInvention | Process for the preparation of phenylcarbamates |
| abstract | This invention relates to a process for the preparation of an aminoalkyl phenyl carbamate compound of formula 1, n nwherein R 1 and R 2 independently are hydrogen or C 1-6 alkyl; R 3 and R 4 are the same or different and each is a lower alkyl; or R 3 and R 4 together with the nitrogen to which they are attached form a cyclic moiety of a three to eight-member ring, with or without a hetero atom like nitrogen or oxygen; R 5 and R 6 independently are hydrogen, linear, branched or cyclic C 1-6 alkyl, allyl, propargyl or benzyl; or R 5 and R 6 together with the nitrogen to which they are attached form a cyclic moiety of three to eight member ring, with or without a hetero atom like nitrogen or oxygen; the carbon center marked with “*” is racemic or enantiomerically enriched (R)- or (S)-configuration; and pharmaceutically acceptable addition salts, and crystalline and amorphous forms thereof comprising the steps of:n i) converting an amine R 5 R 6 NH to a carbamoylimidazolium salt of formula 3 nn n n n n n n n n n n n n n wherein R 5 and R 6 are as defined above; X − is a counterion and R 7 is an alkyl or aryl group; n n n ii) reacting in a solvent at a controlled reaction temperature the compound of formula 3 with a compound of formula 4, n n n n n n n n n n n n n n n n n n wherein R 1 , R 2 , R 3 , R 4 and “*” are as defined above to give the compound of formula 1; and n n n iii) isolating the compound of formula 1. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10882819-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2020095195-A1 |
| priorityDate | 2007-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 232.