| abstract |
The invention provides 15β-substituted steroidal compounds having selective estrogen receptor activity according to Formula I: n nwherein,n R 1 is H, C 1-5 alkyl, C 1-12 acyl, di-(C 1-5 alkyl)aminocarbonyl, (C 1-5 alkyl)oxycarbonyl or sulfamoyl, R 2 is H, C 1-3 alkyl, C 2-3 alkenyl or C 2-3 alkynyl, each of which may be optionally substituted with a halogen, R 3 is C 1-2 alkyl, ethenyl or ethynyl, each of which may be optionally substituted with a halogen, and R 4 is H or C 1-12 acyl. |