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filingDate 2008-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2010-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-7838506-B2
titleOfInvention DNA-based aptamers for human cathepsin G
abstract The present research is directed to the identification of non-peptidic inhibitors of cathepsin G characterised by high levels of selectivity and which can be efficaciously used in the treatment and prophylaxis of inflammatory occurrences and procoagulant conditions. The cathepsin G-inhibiting aptamers according to the invention consist of linear DNA or polynucleotide sequences having a chain length of at least 60 nucleotides and being substantially not subjected to undergo efficient base pairing.
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