| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_48de1cfdc993735cdc1c82f96827b33e |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2337-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-96433 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-564 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 |
| filingDate |
2005-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2010-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_59209ebb9f893bbe4124d3d126f840c9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_237eadf56b2838981cb398b1aeef1616
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_35509e1ed7769e58497776a8bc1fe94d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e10e66ac63b049b1142c6307eb9c503e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32fea57ec5f00143419c1336a64cb0d9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1eb73fc9f76b52a148971592a090dc58 |
| publicationDate |
2010-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7811771-B2 |
| titleOfInvention |
Method for the functional determination of mannan-binding-lectin associated serine proteases (MASPs) and complexes thereof |
| abstract |
This invention relates to the field of determining, assaying or quantifying activity of components of the complement system. More particularly, the invention relates to methods for detecting the presence or level of activity in a sample of mannan-binding-lectin associated serine proteases (MASPs) or complexes of such proteases with lectins and to detection of the particular lectins themselves. Provided is a method for determining the activity of a MASP in a sample, comprising incubating the sample with a pro-urokinase comprising at its activation site the consensus sequence Arg/Leu/Gly-Yyy-Arg/Lys-Ile/Leu/Val-Zzz-Gly-Gly cleavable by a MASP, wherein Yyy can be any amino acid and Zzz is preferably an aliphatic amino acid, and determining proteolytic activation of said pro-urokinase. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11613744-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020140101-A1 |
| priorityDate |
2004-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |