| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b2712834895aedb3e68f7ef49125052 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2027
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2054
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-554 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14 |
| filingDate |
2008-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2010-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9bbfcb56882c3c15a3e66aa19bf4abe6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_31dd90e85e8d47fa23a5b5837c53acc5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27b99b3db9fb0241329abd8a0ec2e634 |
| publicationDate |
2010-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7794750-B2 |
| titleOfInvention |
Controlled-release formulations, method of manufacture, and use thereof |
| abstract |
The present invention includes a controlled-release composition having a matrix. The matrix contains a pharmaceutically effective amount of an active agent or a pharmaceutically acceptable salt or solvate thereof, an ionic non-gelling matrix polymer, and a pH modifier. The ionic non-gelling matrix polymer is practically insoluble and unswellable at a first aqueous fluid pH and is soluble at a second aqueous fluid pH. The pH modifier is present in an amount to control the release of the active agent from the composition. The controlled-release composition is substantially free of a gelling or swellable excipient and does not contain a functional coating or a lipophilic component. The present invention also provides methods of making and using the controlled-release compositions. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9456985-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8362029-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10940155-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8987291-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10561669-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9023390-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9433625-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009317473-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8632805-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10532030-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9427407-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9402813-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9393207-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9399022-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10016368-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9526704-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9498444-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9789104-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9789105-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9993486-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10064856-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9387177-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2309994-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9855264-B2 |
| priorityDate |
2008-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |