Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a819eda0adf22936a52362eeebb9fb4 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-525 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-525 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
filingDate |
2001-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2010-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb581111853920f8d735e893ba94e28b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c025efca7f496d07b9de38a0388609e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_13b9ed4773cc281399c1419b05ece765 |
publicationDate |
2010-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-7786282-B2 |
titleOfInvention |
Nucleic acid molecules encoding TNF-α ligand polypeptides having a CD154 domain |
abstract |
The present invention is directed to an isolated polynucleotide sequence encoding a chimeric TNFα and chimeric TNFα polypeptides. The former have a first nucleotide sequence encoding a domain or subdomain of a tumor necrosis factor ligand other than TNFα, wherein the encoded domain or subdomain lacks a cleavage site, and a second nucleotide sequence encoding a domain or subdomain of native TNFα that binds to a TNFα receptor. The encoded chimeric TNFα is significantly less susceptible to cleavage from the cellular surface and, as a result can increase the concentration of a ligand capable of binding to a TNFα receptor on the surface of a cell. The chimeric TNFα is therefore useful in methods for inducing apoptosis of a cell expressing a TNFα receptor, inducing activation of an immune system cell and treating neoplastic cells, by introducing into the cell of interest an isolated polynucleotide sequence encoding a chimeric TNFα that is expressed on the surface of the cell. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11585813-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10161850-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010267129-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10408734-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7964712-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10585030-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016154286-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9816912-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10739246-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011008842-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10101262-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7906638-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2021139935-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10545084-B2 |
priorityDate |
2001-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |