| abstract |
This invention is directed to a method for treating an inflammatory condition, treating haematological and other malignancies, causing immunosuppression, or preventing or treating transplant rejection in man or other animals which comprises administering to a patient a compound that has the structure of Formula (I) or Formula (II) as defined below, or a pharmaceutically acceptable derivative thereof or pro-drug therefor, wherein R═NH 2 , NHR 1 , NHOR 2 , NHNHR 2 , NHCOR 2 , and R 1 ═C (1-4) alkyl, C (3-6) cycloalkyl, C n , where n=1-3, R 2 =methyl, ethyl, R 3 =alkyl, cycloalkyl, substituted alkyl, substituted cycloalkyl, aryl, heteroaryl, substituted aryl, or substituted hetrecoaryl; wherein R 4 , R 5 ═C (1-4) alkyl. Novel compounds according to Formula (III), wherein R 6 and R 7 are any of H, CH 3 CO, CH 3 CH 2 CO, CH 3 CH 2 CH 2 CO provided that R 6 and R 7 are not both H, or Formula (IV), wherein R 8 and R 9 are any of H, CH 3 CO, CH 3 CH 2 CO or CH 3 CH 2 CH 2 CO, having use in such methods, are also described. |