| abstract |
Disclosed is a phosphate transport inhibiting compound represented by Structural Formula (I): n n n n n n n n n n n n R1 and R2 are independently —H, an electron withdrawing group or a C 1 -C 10 alkyl group. n Y is a covalent bond, a substituted methylene group, an unsubstituted methylene group or —CR1R2P(O)(OH)—. n R3 is a hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups, a substituted hydrocarbyl group optionally comprising one or more amine, ammonium, ether, thioether or phenylene linking groups, a heteroaryl group, a substituted heteroaryl group or a phenyl group substituted with one or more groups selected from —Cl, —Br, —F, —CN, —NO 2 , —OR a , —N(R a ) 2 , —COOR a , —CON(R a ) 2 , —COR a , —S(O)R a , —S(O) 2 R a , —S(O) 2 N(R a ) 2 , —NR a S(O) 2 R a , —NR a COR a , a halogenated lower alkyl group, an aryl group, a substituted aryl group, or a halogenated alkoxy group. n n n n n Each R a is independently —H, lower alkyl, substituted lower alkyl, aryl or substituted aryl. n Each Rb is independently —H, a lower alkyl group, or a phosphate protecting group. |