http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7749977-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_36f12690a646f4748ac2bdf53149359a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06F19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 2006-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1393149355beed2b1095dc23701f8329 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ac6f5e18a4d6b9400fd96c192fd87d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ca3479b3183e860f4812be2d314c502 |
| publicationDate | 2010-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-7749977-B2 |
| titleOfInvention | Therapeutic modulation of the Fas pathway |
| abstract | A method for the identification of genes that are essential for the maintenance of specific cell phenotypes is disclosed. The method includes the initial step of identifying a cell type with a phenotype of interest. Gene inactivation is performed on an aliquot of cells of the cell type of interest. Selection is then performed to an aliquot of the cell culture to which gene inactivation has been applied. Cells which continue to maintain the phenotype following gene inactivation have not had the gene of interest inactivated whereas cells in which genes necessary for maintaining the phenotype have been inactivated have been lost. Utilizing subtraction analysis between treated and untreated aliquots the gene in the cells which has been inactivated that affects the phenotype of interest is identified. Genes that are identified by the method are also disclosed as well as antibodies directed against the gene product of the identified genes. Further a customized kit for the practice of the gene identification method is also disclosed. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8278287-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011230543-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011105591-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012004184-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9464287-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8410069-B2 |
| priorityDate | 1997-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 81.