| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4d5d546aa6cbfb52c137af7cafc36bf4 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-106
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-072
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0312 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-033 |
| filingDate |
2007-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2010-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76b9c9f72274cfaeebc3f6a8d2a91afa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1c34d85b09a82af8493d013b45feefe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b0513e662bf6b1ef40d8ed79a1992de
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b44c084697f3844f230b9a2791d3018
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f62bc275f7cea23cb04e11c0d4f555a4 |
| publicationDate |
2010-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7745688-B2 |
| titleOfInvention |
Model mouse of Alzheimer's disease expressing FAD APP 716 and use thereof |
| abstract |
The present invention provides a non-human model mammal of Alzheimer's disease (AD) containing chimeric amyloid precursor protein (APP) gene capable of producing human amyloid β peptide (Aβ) or a living part thereof, characterized in that Aβ42/Aβ40 ratio at 8-weeks-old is about 7-fold or more (about 140-fold or more in homozygote) higher compared to that of a corresponding wild-type mammal. Moreover, the present invention provides the mammal or a living part thereof, further characterized in that the level of APP expression is not significantly different compared to the corresponding wild-type mammal, and a screening method for a prophylactic and/or therapeutic drug for AD, a biomarker in biological fluids and molecular imaging of amyloid deposition or other pathological changes in the brain for an early diagnosis of AD using the mammal or a living part thereof. |
| priorityDate |
2006-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |