http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7741029-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dd3cc5f84a2f248c8236b641d7454d0c http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3b8cb37a92dea8aea5328a8339313905 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70596 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6883 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 2002-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06971eae1b38bc05ec5af832237de105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66676ba6a7c8ae871284331680741391 |
| publicationDate | 2010-06-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-7741029-B2 |
| titleOfInvention | Diagnosis and treatment of blood disorders |
| abstract | Based on the discovery of the nucleotide and amino acid differences which distinguish the Gov a and Gov b allelic forms of the membrane glycoprotein CD109, and which comprise the biallelic Gov platelet alloantigen system, compositions and methods are provided for determining the Gov genotype and phenotype of individuals. Also provided, on the basis of this discovery, are compositions and methods for treating disorders associated with Gov alloantigen incompatibility, such as the bleeding disorders post-transfusion purpura, post-transfusion platelet refractoriness, and neonatal alloimmune thrombocytopenia. The two allelic forms of CD109 differ by a single amino acid. The Gov a allelic form has Tyr at amino acid position 703 in the CD109 sequence. The Gov b allelic form has Ser at the same position. This amino acid difference is due to a single change, from A for the Gov a allele to C for the Gov b allele, in the CD109 gene. |
| priorityDate | 2001-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.