| abstract |
The invention relates to new 2-substituted D-homo-estra-1,3,5(10)-trienes of general formula I n nin whichn R 2 means a C 1 -C 8 -alkyl group, a C 1 -C 8 -alkyloxy group or a halogen atom, R 13 means a hydrogen atom or a methyl group, R 17 means a hydrogen atom or a fluorine atom,n nas well as their pharmaceutically acceptable salts,n ntheir manufacture and use as medicaments for prophylaxis and therapy of estrogen-dependent diseases that can be influenced by inhibition of 17β-hydroxy steroid dehydro-genase type 1. |