| abstract |
The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S. More particularly, the present invention provides compounds having Formula 1: n n n n n n n n n n n n wherein Q is an optionally substituted piperazinyl; andn A, R 5 , R 6 , R 7 , R 8 , R 9 and Ar are substituents. |