http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7732429-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_09fc02a407043ca0a10e2dbe5fcb6159 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-08 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-29 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-13 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-29 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-13 |
| filingDate | 2008-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9db5c113b5cb23fe36026e5c14e39982 |
| publicationDate | 2010-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-7732429-B2 |
| titleOfInvention | Reducing tetracycline resistance in living cells |
| abstract | The present invention provides an improved methodology by which therapeutically to overcome resistance to tetracycline in living cells including bacteria, parasites, fungi, and rickettsiae. The methodology employs a blocking agent such as C5 ester derivatives, or 6-deoxy 13-(substituted mercapto) derivatives of tetracycline, in combination with other tetracycline-type antibiotics as a synergistic combination of compositions to be administered simultaneously, sequentially or concurrently. In another embodiment, certain novel compositions are provided which may be administered alone against, for example, a sensitive or resistant strain of gram positive bacteria such as S. aureus and E. faecalis . The concomitantly administered compositions effectively overcome the tetracycline resistant mechanisms present such that the cell is effectively converted from a tetracycline-resistant state to a tetracycline-sensitive state. |
| priorityDate | 1991-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 420.