http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7722913-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a42f5611cbbbdabd4b5ee91ce86f6783 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-14865 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61B5-14532 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L33-00 |
| filingDate | 2005-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa14f4bfa11c8b4e9f2a5b91f3eaa525 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dfb00dffd35b22e904035e4c62b182b6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd079eb7c494ca107f4f4b7c22709db0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4007e6a600f7de193062d7f512544b7e |
| publicationDate | 2010-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-7722913-B2 |
| titleOfInvention | Implantable enzyme-based monitoring system having improved longevity due to improved exterior surfaces |
| abstract | An implantable enzyme-based monitoring system suitable for long term in vivo use to measure the concentration of prescribed substances such as glucose is provided. In one embodiment, the implantable enzyme-based monitoring system includes at least one sensor assembly, an outer membrane surrounding the sensor assembly and having a window therein, and a polymeric window cover affixed to the outer membrane and covering the window. Preferably, the outer membrane of the monitoring system is silicone and the window cover is a polymer of 2-hydroxyethyl methacrylate (HEMA), N,N,-dimethylaminoethyl methacrylate (DMAEMA) and methacrylic acid (MA). Also provided herein is an implantable enzyme-based monitoring system having at least one sensor assembly, an outer membrane surrounding the sensor assembly and a coating affixed to the exterior surface of the outer membrane, wherein the coating resists blood coagulation and protein binding to the exterior surface of the outer membrane. Preferably, the coating is polyethylene glycol (PEG) and heparin in an 80:20 molar ratio. Finally, provided herein is a method of coating the exterior surface of the outer membrane of an implantable enzyme-based monitoring system comprising the steps of forming hydroxyl groups on the silicone surface by plasma etching; reacting the silicone surface with amino functionalized silane, thereby forming amino groups on the silicone surface; simultaneously, covalently binding polyethylene glycol (PEG) and heparin to the amino groups; and ionically binding heparin to the monitoring system surface. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9839378-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2859911-A1 |
| priorityDate | 1997-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 70.