| abstract |
A method of inhibiting or reducing occurrence or intensity of pruritus including administering to a patient an effective amount of one or more of the morphinan derivative having a nitrogen-containing cyclic group of the Formula (Ia): n nwherein R 1 is cyclopropylmethyl; R 2 and R 3 are independently hydrogen, hydroxy, C 1 -C 5 alkoxy, C 3 -C 7 alkenyloxy, C 7 -C 13 aralkyloxy or C 1 -C 5 alkanoyloxy; and the Formula (Ia) includes (+), (−) and (±) isomers or the pharmaceutically acceptable acid addition salt thereof. |