| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_59c6a921f33fe0adc58c2b6177184515 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y603-04005 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70 |
| filingDate |
2006-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2010-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e4b1b8bc244c0ca50719dbbd06a9594
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67ccfa5cb2ce8f26b3df3e985df93b88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3375a829fafae519003ce73610e79650 |
| publicationDate |
2010-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7718625-B2 |
| titleOfInvention |
Polynucleotides targeted against the extended 5′-UTR region of argininosuccinate synthase and uses thereof |
| abstract |
The present invention is based in part on the discovery that the upstream open reading frame (uORF) in the extended 5′-untranslated region (5′-UTR) argininosuccinate synthase (AS) mRNA species is functional, and when functional, limits overall AS expression as well as nitric oxide (NO) production. Thus, the extended 5′-UTR AS mRNA species is a mechanism for regulating AS expression and NO production, and provides a target for the treatment of pathophysiological conditions associated with vascular endothelial dysfunction and characterized by impairment of NO production, such as heart failure, hypertension, hypercholesterolemia, atherosclerosis, and diabetes. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015050738-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10822369-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017161043-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10758558-B2 |
| priorityDate |
2005-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |