| abstract |
The present invention provides compounds of Formula (I): n nor a stereoisomer or pharmaceutically acceptable salt form thereof, wherein the variables A, B, L 1 , L 2 , X 1 , X 2 , X 3 , X 4 , R 4 , R 5 , R 13 , R 14 , R 15 and R 16 are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same. |