Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ef2e9f5ce8630d9b282043b8d060caff |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-204 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0051 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0024 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-4893 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L31-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N37-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L31-16 |
filingDate |
2004-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2010-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af73091e27d7e246b0448983c85b26ea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1f72877fb6dba54b1ffdb14447e540b |
publicationDate |
2010-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-7691381-B2 |
titleOfInvention |
Stabilized biodegradable neurotoxin implants |
abstract |
Biodegradable neurotoxin implants and methods of making and using such implants are provided. Biodegradable neurotoxin implants include a neurotoxin, a biodegradable polymer component, and an acidity regulating component. The biodegradable polymer component is effective in controlling the release of the neurotoxin from the implant when the implant is located in a patient's body. The acidity regulating component is effective in maintaining a pH of the implant in a desired range that may be effective in stabilizing the neurotoxin as the implant biodegrades when the implant is located in a patient's body. In one embodiment, an implant includes a botulinum toxin, a biodegradable polymer, and either monomers from which a biodegradable polymer is derived or oligomers including monomeric units substantially identical to a monomer from which a biodegradable polymer is derived, or a combination of such monomers and oligomers. The oligomers and biodegradable polymer may be derived from a single type of monomer. The implants disclosed herein may be administered to a human or animal patient in which a therapeutic effect is desired for prolonged periods of time. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018039318-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9056059-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010068244-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012093827-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8501187-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010129449-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11723876-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8647639-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10925837-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8007828-B2 |
priorityDate |
2004-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |