| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cd9345fdc7767f7b24226f5bc1984ee1 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4375
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F7-0812 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4375 |
| filingDate |
2007-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2010-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5dabfe99b17050486fd996c881cc2aa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ed40e13c3b9a46c549c5e659950936c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ab69d6913c8a43fe2caaa9074ebfa96a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c5688b7da468683e775d015efd32bc90 |
| publicationDate |
2010-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7687496-B2 |
| titleOfInvention |
C7-substituted camptothecin analogs |
| abstract |
The novel C7-modified camptothecin analogs, and pharmaceutically-acceptable salts thereof, of the present invention: (i) possess potent antitumor activity (i.e., in nanomolar or subnanomolar concentrations) for inhibiting the growth of human and animal tumor cells in vitro; (ii) are potent inhibition of Topoisomerase I; (iii) lack of susceptibility to MDR/MRP drug resistance; (iv) require no metabolic drug activation: (v) lack glucuronidation of the A-ring or B-ring; (vi) reduce drug-binding affinity to plasma proteins; (vii) maintain lactone stability; (viii) maintain drug potency; and (ix) possess a low molecular weight (e.g., MW<600). |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10064880-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11291731-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10293053-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10716801-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11497757-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9931407-B2 |
| priorityDate |
2007-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |