| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a431f1e5f5bd51f2842c97425b320542 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-545 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| filingDate |
2006-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2010-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_533fdd8dc3075d1f650ae363dd37a0a9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c6c8a34890da5423c0619f8b7bdcb67
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5af85d1f096492acf3bfb2713e4c01ea |
| publicationDate |
2010-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7674464-B2 |
| titleOfInvention |
Intracellular interleukin-1 receptor antagonists |
| abstract |
Matrix metalloproteinases are major mediators of tissue destruction in various chronic inflammatory disorders. The present invention demonstrates that over-expression of intracellular isoform of IL-1 receptor antagonist confers to recipient cells resistance to signaling pathways of proinflammatory cytokines (such as tumor necrosis factor alpha and IL-1 beta) that induce matrix metalloproteinase and subsequent tissue degradation. Hence, over-expression of intracellular IL-1 receptor antagonist may inhibit tissue destruction in various inflammatory disorders such as rheumatoid arthritis, other arthritides, degenerative intervertebral disc disease and chronic skin ulcers that occurs in diabetes mellitus and bed-ridden patients. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8853150-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9359405-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10799589-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012122985-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9458216-B2 |
| priorityDate |
2004-03-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |