| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fb7f3e63ad994f526a3b9bb9e598a483
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ff81a650b70e913d3b2524b45e4c7320 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-04 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D285-135
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C243-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C235-66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-185
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D261-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C40B30-04 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D285-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B40-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D261-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C243-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D285-135
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-165
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-185
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C235-66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-543
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-277
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C40B30-04 |
| filingDate |
2004-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2010-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9fa5fab941b3a4b3ea231cb5dee673c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7892e9b9e2ff949af38689e8a427928a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4506b8a99b33d5253d4ad0678bfa350e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_48a839abefd24266a0161a1d4082fd8a |
| publicationDate |
2010-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7662750-B2 |
| titleOfInvention |
Protein-protein interaction antagonist screening libraries based upon 1,4-disubstituted naphthalenes and related scaffolds |
| abstract |
The present invention relates to 1,4-disubstituted naphthalene scaffold compounds and other closely related scaffold compounds. The present invention also relates to combinatorial libraries of such compounds. In addition, the present invention relates to a method of identifying a protein-protein interaction antagonist. The method first involves providing a compound as described herein. Next, the compound is contacted with interacting proteins of a protein-protein interaction target complex, whereby the compound is allowed to compete with the interacting proteins. Then, the activity of the compound for inhibiting formation of the protein-protein interaction target complex is measured. Finally, the compound that inhibits formation of the protein-protein interaction target complex is identified as a protein-protein interaction antagonist. Also disclosed is a method for modulating a protein-protein interaction. The method involves contacting interacting proteins of a protein-protein interaction target with a compound as described herein, whereby the protein-protein interaction between the interacting proteins is modulated. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9809849-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10800742-B2 |
| priorityDate |
2003-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |