| abstract |
An isoflavone derivative is provided. The isoxazole derivative has following formula: n n n n n n n n n n wherein R 1 and R 2 , independently, include C 1 -C 12 alkyl optionally substituted with oxirane, thiirane, aziridine, amino, cycloamino, aminohydroxy or cycloaminohydroxy, and R 3 includes hydrogen, hydroxy or C 1 -C 12 alkoxy optionally substituted with oxirane, thiirane, aziridine, amino, cycloamino, aminohydroxy or cycloaminohydroxy. The invention also provides a pharmaceutical composition for treatment of osteoporosis including an isoflavone derivative or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. |