| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9a947c5b565bf9b9919794f03db37eca |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J49-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J49-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J39-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J41-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J49-07 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate |
2006-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2009-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8e5037966ea33caea985a6e5a5adcf6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2344960e873da8363ba0d238da5b111d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_063ae1112a20c146395d817762b396c4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dcf5fe80822965eb5732cc86dbeafaf8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff1ac9f48e1540303609bf51d4d356d5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb1adcb266874c2d8fd00605f05d68e0 |
| publicationDate |
2009-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7612202-B2 |
| titleOfInvention |
Process for preparing temozolomide |
| abstract |
The present invention provides a process for preparing highly pure Temozolomide base which includes recovery from the purification mother liquors by using an anionic exchange resin. By treating Temozolomide hydrochloride with a mixture of an organic acid, a water miscible organic solvent, and water, Temozolomide free base is obtained in an acidic medium. Due to the high sensitivity of Temozolomide to basic pH values the recovery-including process is especially advantageous because it enables obtaining high yields of highly pure Temozolomide base in acidic conditions. n The process for producing Temozolomide base includes hydrolysis of the starting material 8-cyano-3-methyl-[3H]-imidazo[5,1-d]-tetrazin-4-one in acidic medium to obtain highly pure Temozolomide hydrochloride in high yield. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109399591-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8258294-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109399591-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015062481-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3833342-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020033880-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009326028-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9714250-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012108811-A1 |
| priorityDate |
2005-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |