| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a01d7935508cbe002beb151d4efde669 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39541
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-195
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-425
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-255
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-525
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-75
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-50 |
| filingDate |
2004-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2009-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41fa933ca7208f00bac62fd0e52e93ae
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af52a558c8041bb86f7ab68aa8217650
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ab074bff8e2b1f25d62562b8008ad2a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d51cda0fe025c7a413ef3f1b23d8234
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e60919dca092b8834f0d49ab684d795
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_107734ff04c52a211dceb8505725a48e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7b4bedb57cc11ce9e48c11a466438c9 |
| publicationDate |
2009-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7605166-B2 |
| titleOfInvention |
Methods and compositions for treating rheumatoid arthritis |
| abstract |
This application relates to methods and compositions for treating rheumatoid arthritis by administering a combination therapy comprising methotrexate and an antibody to alpha-4 integrin or an immunologically active antigen binding fragment in therapeutically effective amounts. The application also relates generally to methods and compositions for treating rheumatoid arthritis by administering a combination therapy comprising methotrexate and small molecule alpha-4 integrin antagonist that inhibits the alpha-4 integrin (α4 integrin) interaction with VCAM-1. The invention further relates to methods of preparing the compounds and methods of using the compounds and compositions. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11479617-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3015069-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011189161-A1 |
| priorityDate |
2003-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |