http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7598422-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24e76490bed88751680a5fef9bc73892 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C215-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-08 |
| filingDate | 2007-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a990751488751b9ae3ebf1cb6e6760fa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_efa10d77c6462490309c0eb51a8745f3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4902236b028acac09cc59031dbe61cc3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec80bf4f91c4d7a4bf9df04588af9254 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92811d9b51023e133a63987647b8a19e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_693e55c25b53c20b623f8a61ba742f4b |
| publicationDate | 2009-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-7598422-B2 |
| titleOfInvention | Production of chirally pure amino alcohol intermediates, derivatives thereof, and uses thereof |
| abstract | A method of selectively preparing a chiral 2S-amino alcohol useful in preparation of an amide sulfonated or acylated with alkyl, substituted aryl or substituted heteroaryl is described. The method involves reacting a di-tert-butyl diazene-1,2-dicarboxylate with a (4S)-4-benzyl-3-[(S)-trifluoromethyl-alkyl substituted alkanoyl]-1,3-oxazolidin-2-one to afford a di-tert-butyl 1-(1S,2S)-([(4S)-4-benzyl-2-oxo-1,3-oxazolidine-3-yl]-carbonyl}-trifluoromethyl-alkyl substituted alkyl)hydrazine-1,2-dicarboxylate. This dicarboxylate is then reduced to yield di-tert-butyl 1-(1S,2S)-[trifluoromethyl-alkyl substituted alkyl]hydrazine-1-(hydroxymethyl)-1,2-dicarboxylate. The resulting product is deblocked with an acid to yield the acid addition salt of (2S,3S)-trifluoro-hydrazino-methyl alkan-1-ol. The acid addition salt of (2S,3S)-trifluor-2-hydrazino-methyl alkan-1-ol is hydrogenated in the presence of a suitable metal catalyst to yield the amino alcohol (2S,3S)-2-amino-trifluoro-methyl alkan-1-ol HCl. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7737303-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010016639-A1 |
| priorityDate | 2006-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 291.