| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_83354e53e2d14055a7d44c3b4efac2fd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_04994b7a9d93c8287399a926df5cc7e0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_68fc320430ccf85c772a01e97f51af59 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06G7-58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 |
| filingDate |
2000-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2009-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c30d37c56ca300f8eac6e1089848923
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b20c42101d926298bc22290a7c1f386b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c74fa36dec429f8228fa1941d4071a92 |
| publicationDate |
2009-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7590494-B1 |
| titleOfInvention |
Drug design based on the structure of LTA4 hydrolase |
| abstract |
The present invention relates to an isolated leukotriene A 4 (LTA 4 ) hydrolase, which LTA 4 hydrolase is present in its naturally occurring three dimensional form. It is the first three-dimensional structure of any protein component of the leukotriene cascade and enables a description of the structural basis and molecular mechanisms for the two catalytic activities of LTA 4 hydrolase. Further, the invention also relates to LTA 4 hydrolase complexed with an inhibitor. The structural information provided by the present invention will make possible rational design of enzyme inhibitors, which may be developed into clinically useful anti-inflammatory drugs. |
| priorityDate |
1999-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |