http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7588913-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_adb0e564374fedf34b36103d36e6455a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-00 |
| filingDate | 2004-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_189beddaebd257334afadc93dd8fedd0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bfee40e032f792010d349b18d23c54f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c5cc3f25fbee00f5ab82922d11db42ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e171301584944563592a6959c4892ee3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eba05c9dda55769cf4940315f6f2b23a |
| publicationDate | 2009-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-7588913-B2 |
| titleOfInvention | Process for the preparation of cephradine |
| abstract | The present invention describes a process for preparing cephradine, said process comprising reacting 7-aminodesacetoxy cephalosporanic acid (7-ADCA) with D-dihydrophenylglycine in activated form (DHa) in the presence of an enzyme in a reaction mixture to form cephradine, resulting in a conversion of 7-ADCA into cephradine of at least 70%, wherein the concentration D-dihydrophenylglycine (DH) in the reaction mixture is below 2 wt.%, wherein the conversion of 7-ADCA into cephradine & equals; (n CEF /n 7-ADCA )*100%, wherein n CEF =quantity of cephradine formed (in mole); and n 7-ADCA =total quantity of 7-ADCA added to reaction mixture (in mole). The invention also describes a process for the preparation of cephradine hydrate characterised in that the process comprises: —reacting 7-amino acid desacetoxy cephalosporanic acid (7-ADCA) with DHa in the presence of an enzyme in a reaction mixture to form cephradine; —preparing an aqueous solution comprising at least part of the cephradine; and crystallising the cephradine from said aqueous solution. The invention further describes cephradine hydrate obtainable by a process according to invention. The invention also describes cephradine hydrate with an absorbance at 450 nm of below 0.050. |
| priorityDate | 2003-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 113.