http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7582764-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_452edf09f236371e61e3fd22a06ded78 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2231-348 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-0244 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D453-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-0204 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-0237 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-0271 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C45-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6561 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D453-04 |
| filingDate | 2006-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa3781111c96cbfba8e3f391af687d71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80353567fffce0f8660b354d25ec403e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32ce92dec6b98482997c56e25c67a7c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6be223e1155cbe33e6194c815e995862 |
| publicationDate | 2009-09-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-7582764-B2 |
| titleOfInvention | Asymmetric carbon-carbon-bond-forming reactions catalyzed by bifunctional cinchona alkaloids |
| abstract | One aspect of the present invention relates to quinine-based and quinidine-based catalysts. In certain embodiments, the quinine-based and quinidine-based catalysts contain a hydroxy group at the 6′ position. In certain embodiments, the quinine-based and quinidine-based catalysts contain an O-aryl group or an O-aroyl group at the C9 position. In certain embodiments, the quinine-based and quinidine-based catalysts contain an optionally substituted O-diazene group or an optionally substituted O-benzoyl group at the C9 position. In certain embodiments, the quinine-based and quinidine-based catalysts contain a thiourea at the C9 position. In certain embodiments, the quinine-based and quinidine-based catalysts contain an NH(═S)NH-aryl group at the C9 position. Another aspect of the present invention relates to a method of preparing a chiral, non-racemic compound from a prochiral electron-deficient alkene or prochiral imine, comprising the step of: reacting a prochiral alkene or imine with a nucleophile in the presence of a catalyst; thereby producing a chiral, non-racemic compound; wherein said catalyst is a derivatized quinine or quinidine. In certain embodiments, the nucleophile is a malonate or β-ketoester. In certain embodiments the nucleophile is an alkyl or aryl or aralkyl 2-cyano-2-alkylacetate. In certain embodiments the nucleophile is an alkyl or aryl or aralkyl 2-cyano-2-alkylacetate. n Another aspect of the present invention relates to a method of kinetic resolution, comprising the step of: reacting a racemic aldehyde or racemic ketone with a nucleophile in the presence of a derivatized quinine or quinidine, thereby producing a non-racemic, chiral compound. In certain embodiments, the kinetic resolution is dynamic. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101797519-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3088383-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016173960-A1 |
| priorityDate | 2004-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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