abstract |
The present invention provides a compound having the formula: n nwherein, n and m are 1 ; X 1 and X 2 are O; R 1 is a member selected from unsubstituted phenyl and substituted phenyl; R 2 is a member selected from hydrogen, —CN, —OR 2A , -L 2A —C(O)R 2B , -L 2B —S(O) 2 R 2C ; R 3 is a member selected from unsubstituted benzyl and substituted benzyl; R 4 is a member selected from hydrogen and substituted or unsubstituted alkyl, wherein if R 4 is methyl, then -L 1 -R 1 is not benzyl or —C(O)—O—CH 2 —CH 3 ; and L 1 is a bond; and compositions and methods of using the compounds as glucocorticoid receptor modulators. |