| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_709b4a26ef028713f9b302509eb824d7 |
| classificationCPCAdditional |
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http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-317 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08K5-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08K5-29
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-74 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08K5-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08K5-29
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-00 |
| filingDate |
2004-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2009-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb782e995c135db41111f0f0c3c6eaf4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6827a0d72f3379046dc848b8e9e9911
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1bd45ca08d927fd93b8d53db053c22b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25d9fc1be5809911457cba9b095e09c6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02f8848f1da6460dc17708c8ac9a7860
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ee19040729a1b0e70e706274e1c7c72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65b4556020030833eefd0369c1085291
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43ba8d4e534a9c71b70e617fff6b25fc |
| publicationDate |
2009-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7575918-B2 |
| titleOfInvention |
Tissue-specific and pathogen-specific ribozymes |
| abstract |
The present invention relates to the discovery, identification and characterization of toxic agents which are lethal to pathogens and methods for targeting such toxic agents to a pathogen or pathogen infected cells in order to treat and/or eradicate the infection. In particular, the present invention relates to toxic agents which target bacteria at different stages of the bacterial life cycle, which are delivered alone or in combination to bacteria or bacteria-infected cells. The invention relates to toxic agents which are lethal to diseased cells and methods for targeting such toxic agents to a diseased cell in order to treat and/or eradicate the disease. The present invention relates to promoter elements which are pathogen-specific or tissue-specific and the use of such promoter elements to achieve pathogen-specific or tissue-specific expression of the toxic agent(s) and/or ribozyme(s) of the present invention. Specifically, the invention relates to the delivery of one or more toxic gene products, antisense RNAs, or ribozymes, or combination thereof. The invention provides a novel system by which multiple pathogenic targets may be simultaneously targeted to cause the death of a pathogen, or cell infected with a pathogen. Further, the invention has important implications in the eradication of drug-resistant bacterium and bacterial pathogens. The invention provides a novel system by which multiple targets may be simultaneously targeted to cause the death of a diseased cell. The invention has important implications in the eradication of drug-resistant pathogens (such as antibiotic resistant bacteria) and drug-resistant diseased cells (such as drug-resistant cancer cells). |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006058252-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7704965-B2 |
| priorityDate |
1999-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |