abstract |
The present invention provides exemplary systems and methods for producing dry powder formulations. In one embodiment, a system ( 10 ) includes at least one conditioning zone ( 12 ) having an inlet ( 20 ) to introduce an atomized formulation ( 18 ) into the conditioning zone. A controller ( 14, 16 ) controls temperature and relative humidity of the airflow into the conditioning zone to allow amorphous-to-crystalline transformation of the atomized formulation. In another embodiment, the formulation is suspended in the conditioning zone for a residence time of sufficient duration to allow surface orientation of surface active components. A dryer ( 24 ) is coupled to the conditioning zone to dry the atomized formulation, and a collector ( 28 ) collects the formulation in powder form. |