http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7572909-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_26da3723d11a0786897640eceb4d464f |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-173 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-167 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-173 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-167 |
| filingDate | 2003-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2a8054997671ca4b3c12f50aaba8f7fa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a44aa3ae0f391ca3956d05266639b92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37a001a81301089af5cc9882f042936d |
| publicationDate | 2009-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-7572909-B2 |
| titleOfInvention | Method for the preparation of 2-halo-2′-deoxyadenosine compounds from 2′-deoxyguanosine |
| abstract | The present invention is a method for preparing 2-halo-6-aminopurines, and more specifically for preparing the clinical agent cladribine (2-chloro-2′-deoxyadenosine, CldAdo, 4), a drug of choice against hairy-cell leukemia and other neoplasms, from 2-amino-6-oxopurines, which are readily obtained from the naturally occurring compound 2′-deoxyguanosine. According to the methods of the present invention, the 6-oxo group of a protected 2′-deoxyguanosine (1) is converted to a 6-(substituted oxy) leaving group, or alternatively to a 6-chloro leaving group, the 2-amino group is replaced with a 2-chloro group, the 6-(substituted oxy) leaving group, or alternatively the 6-chloro leaving group, is replaced with a 6-amino group or, alternatively, a 2,6-dichloro substituted compound is selectively replaced with a 6-amino group, and the protecting groups are removed. |
| priorityDate | 2002-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 208.