| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f6e41a99a43ce48aae795c1055583b2a |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-061
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-062
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-067
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K17-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-065
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K17-00 |
| filingDate |
2003-06-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2009-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c5d64591487b35f7e1a461877baa7dab
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5edf30c2d3306fd8305931284c3cc600
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d6d1775bd97ef821827f32e101ec308
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8ff6674c85ba828918e0982aa67b8da5 |
| publicationDate |
2009-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7566697-B2 |
| titleOfInvention |
Carboxy protection strategies for acidic C-terminal amino acids in chemical ligation of oligopeptides |
| abstract |
The present invention provides methods of assembling oligopeptides or polypeptides in a native chemical ligation reaction that eliminates the formation of unwanted side products resulting from the presence of an unprotected acidic C-terminal oligopeptide thioester. An important aspect of the present invention is providing side chain protected acidic C-terminal oligopeptide thioesters. The present invention is useful in methods for chemical synthesis of oligopeptides, polypeptides and proteins and improves the efficiency of native chemical ligation reactions, particularly where aspartyl or glutamyl peptide fragments are used to assemble an oligopeptide, polypeptide or protein product. |
| priorityDate |
2002-06-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |