| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0597f9c318d2aeca86db94711c516383 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-54 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-08 |
| filingDate |
2006-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2009-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4213f3c99f7fb94f4c48ba51c6460337
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f0b3dc100055d0375301feebfccda0c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd4f36694762c781e20348b0aab1c46e |
| publicationDate |
2009-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7541474-B2 |
| titleOfInvention |
Catalyzed process of making C-5-substituted heterocyclic inhibitors of 11β-hydroxy steroid dehydrogenase type 1 |
| abstract |
The invention provides a process for preparing 11 β-hydroxy steroid dehydrogenase type 1 inhibitors of formula 2 via a catalyzed reaction between a compound of formula 1 and a compound of formula R 2 LG in the presence of base: n nwhere R 1 , R 2 , X, Y, and LG are described in the specification. Exemplary catalysts contain palladium and one or more phosphine ligands. The process can be performed in a stereoselective manner to give enantiomerically enriched products. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012051139-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11730726-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11395820-B2 |
| priorityDate |
2005-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |