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filingDate 2007-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2009-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d4618bd7be232bdde89e2ba56df758e
publicationDate 2009-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-7538183-B2
titleOfInvention HPV vaccine comprising peptides from host cell proteins
abstract The present invention relates to a human papillomavirus (HPV) vaccine that comprises peptides from host cell proteins and more particularly, a vaccine that is directed against cancers that are associated with HPV infections, such as cervical cancer, head and neck cancer and skin cancers. The peptides comprise fragments of host cell proteins that have been targeted for degradation by HPV proteins, such as E6 and E7 and are presented on the surface of HPV infected cells in relatively large amounts. These peptides can be recognised by CTL and elicit an immune response, and are therefore ideal tumour-specific markers. The invention also relates to novel peptide: peptide complexes such as peptide/HLA complexes and their use in a tumour-specific vaccine.
priorityDate 2004-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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