| abstract |
The present invention provides multi-antigenic constructs comprising one or more carbohydrate antigens having the formula: n n n n n n n n n n n n n n n n n n n wherein R 1 , R 2A , R 2B , R 3 , R 4 , W 1 , W 2 and W 3 are as defined herein; and additionally provides compositions thereof, and methods for their use in the treatment and/or prevention of HIV infection, and methods for inducing HIV-specific antibodies in a subject, comprising administering to a subject in need thereof, an effective amount of any of the inventive compounds as disclosed herein, either in conjugated form or unconjugated and in combination with a suitable immunogenic carrier. In another aspect, the invention provides an antibody or antibody fragment which binds specifically to a gp120 glycan or glycopeptide of the invention. |