| abstract |
Novel heterocyclic dihydropyrimidine compounds useful as inhibitors of potassium channel function (especially inhibitors of the K v 1 subfamily of voltage gated K + channels, especially inhibitors K v 1.5 which has been linked to the ultra-rapidly activating delayed rectifier, which have the structure n nstereoisomers including enantiomers thereof and diastereomers thereof, or a pharmaceutically acceptable salt thereof,n nwhereinn Q is alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, cycloheteroalkyl, substituted cycloheteroalkyl or n n n n n n n n n n n n which is aryl, substituted aryl, heteroaryl or substituted heteroaryl; R 3 is n n n n n nwherein R 1 , R 2 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and R 10 are defined herein.n n Methods of using such compounds in the prevention and treatment of arrhythmia and I Kur -associated conditions, and pharmaceutical compositions containing such compounds are also provided. |