| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5a82c00e406f3cf98a6e6770f84426c3 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L31-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3895
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0062 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-38 |
| filingDate |
2002-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2009-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0c59b448b22d097b46ae026f4299922
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_493879fa57300196ed00bb57abf30459 |
| publicationDate |
2009-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7504258-B2 |
| titleOfInvention |
Tissue engineered cellular sheets, methods of making and use thereof |
| abstract |
The disclosure provides methods and composition to build living tissue covered stents and the like. These tissue coated stents provide a barrier against cell migration to the lumen of the vessel. Since the tissue can surround and envelope the stent, foreign body responses to the stent material are reduced and delayed. The tissue coating is also relatively impermeable to transmural flow, so the wrapped stent can act as a bypass vessel. The tissue is also robust enough to act as a stand alone vessel, without requiring the presence of the metallic stent. These stents can be endothelialized to reduce thrombosis. The genetic modifications described in this disclosure allow for functional organs to be built that express agents that are anti-restenotic or anti-thrombogenic. The use of tissue manipulation devices further allows for the assembly of complex tissue engineered organs. The tissue manipulation devices provide a method of anchoring the tissue sheets to the cell culture substrate to promote prolonged maturation and subsequent increased mechanical strength. The tissue manipulation devices also provide a technique to facilitate removal of the sheet from the culture container and subsequent production steps to assemble more complex three dimensional organs from the robust sheet. The tissue manipulation devices also facilitate automated handling of the sheets in the assembly processes. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009233356-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007178588-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7744526-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10293082-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10987449-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010189712-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11034928-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10660754-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006286664-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010040663-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8076137-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10022225-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11773362-B2 |
| priorityDate |
2001-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |