| abstract |
There is provided an aminophenoxyacetic acid derivative of the following formula (I): n nwherein, R 1 , R 2 , R 3 and R 4 are, independent from each other, alkoxy group, alkyl group or aryl group, etc.; E 1 and E 2 are oxygen atom, sulfur atom, etc.; n is 0 to 5; X and Y are alkylene group, cycloalkylen group, or alkenylen group; Q is phenyl group which may be substituted or benzoyl group, etc, or a pharmaceutically acceptable salt thereof.n n These compounds have neuroprotective effects by inducing calbindin D28Kd, one of Ca 2+ -binding proteins. |