| abstract |
The present invention is related to benzazole derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such benzazole derivatives. Said benzazole derivatives are efficient modulators of the JNK pathway, they are in particular efficient and selective inhibitors of JNK2 and/or 3. The present invention is furthermore related to novel benzazole derivatives as well as to methods of their preparation. n nX is O, S or NR 0 , with R 0 being H or an unsubstantiated or substituted C 1 -C 6 alkyl;n nG is an unsubstantiated or substituted pyrimidinyl group. |