| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c999fee6428152a996011d506925c2d7 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-24 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-63 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-02 |
| filingDate |
2007-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2008-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0de9c318d7651971d68d376ea033f9c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67ccbd9c4a9284f5b28c8dc4d956a2db
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65140a4d557438a45264b7b99f3a469c |
| publicationDate |
2008-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7459582-B2 |
| titleOfInvention |
Methods for producing nateglinide crystals |
| abstract |
There is provided methods for producing nateglinide crystals, which comprises the steps of adding an acid(s) to a reaction mixture containing nateglinide to make it acidic, the reaction mixture being obtained by reacting trans-4-isopropylcyclohexylcarbonyl chloride with D-phenylalanine in a mixed solvent of ketone solvent and water in the presence of an alkali; and then adjusting the temperature of the mixture to 58° C. to 72° C. and the concentration of ketone solvent to more than 8 wt % and less than 22 wt % to conduct precipitation of nateglinide crystals. This producing method is the industrially beneficial methods for crystallization of nateglinide. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009076304-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009076301-A1 |
| priorityDate |
2000-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |