| abstract |
Remedies for dry eye and diseases associated with dry eye which contain as the active ingredient peptides represented by the general formula (I):n nH-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-X 1 -Gln-X 2 -Ala-Val-X 3 -X 4 -Tyr-Leu-X 5 -X 6 (SEQ ID NOS: 26-36) (I)n nwherein X 1 , X 3 and X 4 represent Lys or Arg, respectively; X 2 represents Met, Leu or nLeu; X 5 represents a chemical bond, Asn, Asn-Ser, Asn-Ser-Ile, Asn-Ser-Ile-Leu(SEQ ID NO: 37) or Asn-Ser-Ile-Leu-Asn-X 7 (SEQ ID NOS: 38-43) (wherein X 7 represents a chemical bond, Gly, etc.); and X 6 represents —OH or —NH 2 , or pharmaceutically acceptable salts thereof:. |