| abstract |
The invention relates to compounds of general formula (I): n n n n n n n n n n n n where R 1 represents H or a (C 1 -C 4 )alkyl, —CO(C 1 -C 4 )alkyl, (C 1 -C 4 )alkylphenyl or —CO-phenyl group, said phenyl optionally being substituted; R 2 represents H, a halogen atom, an —S(O) z (C 1 -C 4 )alkyl group, where z is equal to 0, 1 or 2, an —NHSO 2 (C 1 -C 4 )alkyl group, an —NHSO 2 -phenyl group or an —NHSO 2 —(C 1 -C 4 )alkylphenyl group, said phenyl optionally being substituted; R 3 represents an —X—R 4 group—in which X represents a bond, an oxygen atom or a —CH 2 — group and R 4 represents H or a —CR 5 R 6 —COOR 7 group, where R 5 , R 6 and R 7 independently represent H or a (C 1 -C 4 )alkyl group—a phenyl group optionally substituted or fused with a dioxolane group, a —CO—NR 8 R 9 group—where R 8 represents H, a (C 1 -C 4 )alkyl group or a (C 1 -C 4 )alkyl(C 1 -C 4 )alkoxy group and R 9 represents a (C 1 -C 4 )alkyl(C 1 -C 4 )alkoxy group, a —(CH 2 ) n -A group, where n is equal to 0, 1, 2, 3 or 4 and where A represents an indolyl group, a fluorenyl group or a phenyl group which is substituted, an optionally substituted —NH-phenyl group or a —CH(R 10 )—(CH 2 ) n —COOR 11 group, where n is 0, 1, 2 or 3 and where R 11 represents H or a (C 1 -C 4 )alkyl group and R 10 represents H, a (C 1 -C 4 )alkyl group or a —CH 2 -phenyl group, said phenyl optionally being substituted, or a —COOR 12 group, where R 12 represents H or a (C 1 -C 4 )alkyl group; their process of preparation and their therapeutic application. |