Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1ba6c2fc3f40eccda7665fbb5a961f41 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5258 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5256 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16222 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2770-36162 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2770-36143 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16234 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-16122 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2820-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2840-203 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2770-36161 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-12 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N63-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N7-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-86 |
filingDate |
2004-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2008-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c4f72b74c7f2b4be724d00cacf4fa5c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ecba0892cd5579a009fd75ac6d3c223 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7f23f1d0e4bf86f46accf43300bbd9d |
publicationDate |
2008-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-7442381-B2 |
titleOfInvention |
Alphavirus replicons and helper constructs |
abstract |
The present invention provides a recombinant nucleic acid comprising: a first nucleic acid sequence encoding a 5′ alphavirus replication recognition sequence; at least one second nucleic acid sequence encoding an alphavirus nonstructural protein; at least one alphavirus subgenomic promoter; at least one IRES element; at least one heterologous nucleic acid; and a third nucleic acid encoding a 3′ alphavirus replication recognition sequence. Further provided are methods of making alphavirus particles comprising a recombinant nucleic acid of this invention and methods of using the compositions of this invention. Also provided is a recombinant helper nucleic acid comprising: a first nucleic acid sequence encoding a 5′ alphavirus replication recognition sequence; an alphavirus subgenomic promoter; an IRES element; a second nucleic acid encoding an alphavirus structural protein; and a third nucleic acid encoding a 3′ alphavirus replication recognition sequence. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9597414-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9730997-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11696923-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11690864-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11690865-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11690861-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11690862-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11690863-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11666534-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11655475-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8822427-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012100574-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2625033-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11730754-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8828961-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012058072-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012058073-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11707482-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11717529-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015024002-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11759475-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8892184-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11759422-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014193484-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11766401-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11739334-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013066665-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013103434-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013177133-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014227346-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11744887-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11759515-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11773395-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11786467-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8460913-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9052321-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9650634-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010118252-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10434187-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8680258-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009075384-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11596645-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7850977-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11638693-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11638694-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11639370-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10004797-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11421248-B2 |
priorityDate |
2003-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |