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grantDate 2008-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2008-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-7417226-B2
titleOfInvention Mass spectrometer
abstract An Atmospheric Pressure Chemical Ionisation (“APCI”) ion source is disclosed comprising a housing 14 having a corona discharge chamber 1 , a reaction chamber 2 and a passage 6 connecting the corona discharge chamber 1 to the reaction chamber 2 . Reagent ions are formed in the corona discharge chamber 1 and pass to the reaction chamber 2 via the passage 6 . Analyte is sprayed into a heated tube 3 . Low to moderately polar analyte molecules pass from the heated tube 3 into the reaction chamber 2 whereupon the analyte molecules are ionised by interacting with reagent ions. In contrast, highly polar analytes are ionised by thermal ionisation processes within the heated tube 3 and hence highly polar analyte ions pass into the reaction chamber 2 . Analyte ions entering the reaction chamber 2 are substantially shielded from the effects of an electric field generated in the corona discharge chamber 1 as part of the process of generating reagent ions. The APCI ion source according to the preferred embodiment is able to optimally ionise a sample containing both low to moderately polar analytes and also highly polar analytes.
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