| abstract |
The present invention relates to a compound formula[I]: n nwhereinn n n n n n n n n n n X is bond, —CH 2 —, —O— or —NH—, n R 1 and R 12 are each independently hydrogen, halogen, lower alkyl, etc., n R 2 is hydrogen or optionally substituted lower alkyl, n R 3 is hydrogen or an amino protective group, n R 4 , R 5 and R 6 are each independently hydrogen or optionally substituted lower alkyl, n R 7 is -Z-R 13 , in whichn Z is bond, etc., and R 13 is carboxy, lower alkoxycarbonyl, (lower alkylsulfonyl)carbamoyl or lower alkanoylsulfamoyl, n n R 8 is —Y—R 9 , in whichn Y is bond, —CH 2 —, —O—, —S—, etc., and R 9 is hydrogen, lower alkyl, cyclo(lower)alkyl, etc., and n n R 11 is hydrogen, lower alkyl, lower alkoxy, etc., or a salt thereof. n n n The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence. |