| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d5d9182c8aaf6d29a48802db18c7abbb |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-14 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-407
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-04 |
| filingDate |
2005-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2008-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_165d508847d0ec677f92e22b7bb4d664
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb32d86c1b971f0b1305b95ad97033fe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_142c9beb49908e600e1a4c14edff2979
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6cdfd6f4b4a22d185b13d6c2ecbb09c4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_866347a9234d45b59aaf32f889f8c102
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08f762f3976777b2b4903b843032eeaa |
| publicationDate |
2008-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7414069-B2 |
| titleOfInvention |
Antituberculosis compounds, Hirsutellones A, B, and C |
| abstract |
Three new alkaloids, Hirsutellones A, B, and C, are produced in cultures of fungus such as Hirsutella nivea strain BCC 2594 and Trichoderma sp. strain BCC 7579. The Hirsutellones exhibited potent growth inhibitory activity against Mycobacterium tuberculosis (H37Ra strain) with an MIC value of 0.78 μg/ml, while showing weak or no cytotoxicity to mammalian cells. Therefore, Hirsutellones and pharmaceutical compositions containing Hirsutellones may be useful for the treatment of tuberculosis. Also described herein are methods of isolating the Hirsutellones. |
| priorityDate |
2004-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |