| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e0daec85fdd4a4c04e22225e70a5cd9 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A90-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-125
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-385
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2035-124 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5094
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0647
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5008
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-502
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5041
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5073
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0789
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate |
2001-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2008-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61ee1792b09773247726939ef3985d12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0a8c488bf8e5869be4b98e7df2ed983 |
| publicationDate |
2008-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7399633-B2 |
| titleOfInvention |
Methods for immortalizing cells |
| abstract |
The present invention provides methods for immortalizing precursor cells that are non-terminally differentiated cells such as stem cells, said methods comprising culturing the precursor cells in the presence of a Notch agonist and one or more growth factors that support the proliferation but not differentiation of the non-terminally differentiated cells. The present invention further provides methods to induce the differentiation of immortalized cells, comprising growing the cells in the presence of a Notch agonist and at least one growth factor which supports the differentiation of the cell into a more specialized cell type. The immortalized and/or differentiated cells of the invention can be used to repopulate cell populations that have been diminished, for example as a result of infection or exposure to certain drugs. The invention further provides a cell culture comprising a population of non-terminally differentiated cells immortalized by the methods of the present invention and kits comprising reagents that promote the immortalization of precursor cells. The invention further provides methods for screening for Notch modulators and for identifying genes involved in processes of cellular differentiation. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3590520-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023150393-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014110020-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11466252-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3097916-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8415303-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7781186-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3097917-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11185536-B2
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016176652-A2
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015166961-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006160216-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011127472-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007134239-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4049665-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011127470-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013086436-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10813949-B2
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10898492-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017161001-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019236766-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014369973-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3995142-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4083062-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017218948-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11286487-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3943090-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007166824-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016118780-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016210292-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017132530-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9834755-B2 |
| priorityDate |
2000-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |