| abstract |
The hexuronic acid derivative represented by the following formula 1 or a salt thereof is used as an active ingredient of a heparin/heparan sulfate sulfotransferase inhibitor. n n n n n n n n n n In the formula, each of R 1 , R 2 , and R 3 independently represent(s) SO 3 − or H which may have a substituent, provided that at least one thereof represents SO 3 − ; X represents OR 4 , SR 4 , N(R 4 ) 2 , or C(R 4 ) 3 , R 4 independently represents H, alkyl, alkenyl, alkynyl, acyl, aryl, or aralkyl group; one of R 5 and R 6 represents COOH while the other represents H; and the wavy line represents α-glycosidic bond or β-glycosidic bond. |